TY  - JOUR
T1  - Serum Iron's Predictive Value for Heart Failure with Reduced Ejection Fraction (HFREF) in Patients with Acute ST‐Segment Elevation Myocardial Infarction
AU - Raghunandhan, K. AU - Kiruthika, R. AU - Fahrudeen, S. 
JO  - Research Journal of Medical Sciences
VL  - 19
IS  - 4
SP  - 148
EP  - 153
PY  - 2025
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2025.148.153
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2025.148.153
KW  - Serum iron
KW  - st‐segment elevation myocardial infarction
KW  - heart failure with reduced ejection fraction
KW  - predictive biomarker
KW  - cardiovascular illness
AB  - Heart failure with reduced ejection fraction (HFrEF) following acute
ST‐segment elevation myocardial infarction (STEMI) considerably affects
morbidity and death rates. Identifying predictive biomarkers for HFrEF
can facilitate early management and enhance results. This prospective
cohort study included 50 patients following STEMI, evaluating the
predictive significance of baseline serum iron concentrations for the
onset of HFrEF during a six‐month period. Statistical analysis included
logistic regression to account for relevant confounders. The prevalence
of HFrEF at six months was 40%. Patients with HFrEF exhibited markedly
lower baseline blood iron levels than those without (58.4 μg/dL vs. 70.1
μg/dL, P=0.033). Multivariate analysis indicated that a 10 μg/dL reduction
in serum iron correlated with a 25% elevation in the likelihood of
developing HFrEF (aOR 1.25, 95% CI 1.07‐1.45, P=0.005). The sensitivity
and specificity of serum iron levels in predicting HFrEF were 60% and
66.7%, respectively. The serum iron levels upon admission following
STEMI are a strong predictor of the development of HFrEF within six
months. These findings support the incorporation of serum iron level
assessment in the post‐STEMI evaluation, underscoring the possibility of
early treatment measures.
ER  -