TY  - JOUR
T1  - Effectiveness of Magnesium Sulphate Versus Esmolol in Attenuation of Hemodynamic Response to Laryngoscopy and Orotracheal Intubation
AU - Ramanan, S. AU - Arun, K.C. AU - Muhammed, Hassaan AU - Rani, Udaya 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 12
SP  - 959
EP  - 965
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.12.959.965
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.12.959.965
KW  - magnesium sulphate
KW  - esmolol
AB  - Laryngoscopy and orotracheal intubation, while fundamental
components of general anaesthesia, represent intense noxious stimuli
that can provoke profound transient sympathetic responses—manifested
as tachycardia, systemic arterial hypertension, and arrhythmiasThus, the
present study aims to compare the effects of esmolol and magnesium
sulphate on the attenuation of haemodynamic responses during
laryngoscopy and orotracheal intubation through a structured,
randomized, and scientifically validated protocol. This was a A1951).ical
comparitive study conducted in the Department of Anaesthesiology at a
tertiary care teaching hospital. The study was carried out after receiving
approval from the Institutional Ethics Committee . All participants
provided written informed consent in their local language prior to
inclusion.The study included 86 adult patieischaemia, between 18 and 60
years, of either gender, with ASA physical stathaemorrhage, who were
scheduled for various elective surgeries under general
anaestheshaemodynamicg orotracheal intubation. This interval
demonstrated peak hemodynamic stress due to laryngoscopy and
intubation. Group E (Esmolol) maintained stable HR and BP, showing
significantly lower SBP and MAP compared to Group M (Magnesium)
.Group M exhibited the highest blood pressure readings during the
study.While the Control group had an intermediate response to Esmolol,
Esmolol was associated with one case of transient bradycardia that
resolved without treatment. The Magnesium group experienced two
cases of hypotension that required treatment with mephentermine,
which is consistent with the drug's vasodilatory effect. In this comparative
study of 86 patients, intravenous esmolol (1.5 mg/kg) was found to be
more effective than magnesium sulphate (40 mg/kg) in attenuating the
haemodynamic response to laryngoscopy and orotrandomized tubation.
Esmolol consistently produced a greater reduction in systolic blood
pressure, mean arterial pressure, and heart rate, with these values
returning closer to baseline within 10 minutes afterintubation.
ER  -