TY  - JOUR
T1  - Correlation Between Clinical and Pathological Factors of Gastric Cancer ‐ A Retrosoective Study in A Tertiary Care Hospital
AU - Sai Mounika, Kummara Gnana AU - Abhiram, A. AU - Rao, Channanna AU - , Deepanraj 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 12
SP  - 895
EP  - 899
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.12.895.899
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.12.895.899
KW  - Gastric carcinoma
KW  - gastrectomy
AB  - Gastric cancer is a complex and heterogeneous disease, ranking as the
fifth most prevalent cancer and the third leading cause of cancer‐related
mortality globally in 2018. A deeper understanding of the proliferative
and apoptotic changes in gastric cancer, along with the identification of
novel biomarkers for cancer detection and therapeutic targets, could
advance diagnosis, treatment, and prevention efforts. Previous research
indicates that 0.7 million individuals succumb to gastric cancer annually,
with approximately 70% of cases exhibiting a significantly higher mortality
rate compared to other malignancies, such as liver and breast cancers.
This retrospective study was conducted from July 2023 to November
2024 at a tertiary care center in the PES Institute of Medical Sciences and
Research in Andhra Pradesh. The inclusion criteria comprised patients
aged = 18 years, histologically confirmed cases of gastric
adenocarcinoma, patients who underwent gastrectomy (partial/total) or
biopsy for unresectable tumors, and patients who provided informed
consent. Of the 80 patients, 50 (62.5%) were male and 30 (37.5%) were
female; 50 (62.5%) underwent distal gastrectomy, 5 (6.25%) underwent
proximal gastrectomy through the abdomen, 15 (18.75%) had proximal
gastrectomy via the thorax, and 10 (12.5%) underwent complete
gastrectomy. Distal and complete gastrectomy demonstrated greater
lymph node clearances than the other surgical techniques. Postoperative
complications occurred in eight patients (10%), including gastric retention
(20%), anastomotic leakage (10.5%), incision infection (9.25%), wound
disruption (5.25%), and thoracic cavity effusion (5.25%). Complications
were more prevalent in individuals undergoing proximal gastrectomy
through the abdomen (30%). Overall, the mortality rate was 1.25% (1/80).
The diameter of the neoplasm was associated with the depth of
infiltration and the rate of lymphatic metastasis, although hemoglobin
level was not. Twelve (15%) of 80 patients had early gastric cancer (EGC)
with lymph node metastases. This retrospective investigation found that
the clinicopathological characteristics of gastric cancer varied according
to sex, location, and tumor diameter.
ER  -