TY  - JOUR
T1  - Clinicopathological Correlation of Vesiculobullous Lesions of Skin: An Institutional Study
AU - Roselin, S. AU - Rajan, G. AU - Vijayaragavan, Lilarani 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 12
SP  - 856
EP  - 859
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.12.856.859
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.12.856.859
KW  - Vesiculobullous lesions
KW  - Pemphigus vulgaris
KW  - Bullous pemphigoid
KW  - Histopathology
KW  - Immuno fluorescence
KW  - Clinicopathological correlation
AB  - Vesiculobullous skin lesions represent a heterogeneous group of
disorders characterized by intraepidermal or subepidermal blister
formation due to varied etiologies including autoimmune, infectious,
genetic, or drug‐induced causes. Accurate diagnosis requires correlation
between clinical presentation and histopathological features, often
supplemented by immunofluorescence studies. To study the clinical and
histopathological correlation of vesiculobullous skin lesions in patients
presenting to a tertiary care institution. To evaluate the
clinicopathological correlation of vesiculobullous skin lesions in patients
presenting to a tertiary care hospital. The most common age group
affected was 41–60 years, with a slight female predominance.
Autoimmune blistering disorders constituted the majority of cases
(62.7%), with pemphigus vulgaris being the most frequent (34.7%),
followed by bullous pemphigoid (18.7%). Infectious and hereditary
blistering diseases accounted for 21.3% and 10.7% respectively.
Clinicopathological correlation was established in 89.3% of cases.
Histopathology revealed intraepidermal blisters in pemphigus group and
subepidermal blisters in pemphigoid group. Direct immunofluorescence
helped confirm diagnosis in selected cases. A multidisciplinary approach
combining clinical features, histopathology, and immunofluorescence is
essential for accurate diagnosis and classification of vesiculobullous
lesions. High clinicopathological correlation highlights the utility of skin
biopsy in guiding targeted therapy and improving patient outcomes.
ER  -