TY  - JOUR
T1  - Analysis of the Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux Disease: A Clinical Evaluation in a South Indian Population
AU - Narayanan, G. AU - Aurobindo, B. AU - Nath, H.S. 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 12
SP  - 815
EP  - 819
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.12.815.819
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.12.815.819
KW  - Laryngopharyngeal reflux
KW  - proton pump inhibitors
KW  - RSI
KW  - RFS
KW  - South India
KW  - lifestyle modifications
AB  - Laryngopharyngeal Reflux (LPR), an extra-esophageal manifestation of
GERD, presents with nonspecific symptoms and often lacks classical GERD
features. Proton Pump Inhibitors (PPIs) are widely used in LPR treatment,
though their effectiveness remains debated. This study evaluates the
clinical efficacy of PPI therapy in LPR management in a South Indian
population. A prospective quasi-experimental study was conducted over
six months in a tertiary center in South India. Adults aged 18-60 years
with clinical symptoms of LPR (RSI $13 and RFS >7) were prescribed
pantoprazole 40 mg twice daily for 8 weeks. RSI and RFS scores were
assessed pre- and post-treatment. Lifestyle modifications were also
documented. Data were analyzed using paired t-tests and logistic
regression. Among 100 participants (mean age 38.6±10.5 years, 56%
female), the mean RSI score improved from 20.8 to 10.2 and RFS from 9.7
to 5.2 (p<0.001). Complete response (RSI <13 and RFS <7) was seen in
58%, partial in 28% and no response in 14%. Lifestyle modifications
significantly improved treatment outcomes (p<0.01). Logistic regression
identified symptom severity and lifestyle adherence as independent
predictors of treatment response. PPI therapy significantly improves
symptoms and laryngoscopic findings in LPR patients, particularly when
combined with lifestyle changes. A tailored, multifactorial approach is
essential for optimal management of LPR in Indian settings.
ER  -