TY  - JOUR
T1  - A Systematic Review on Doxorubicin‐induced Cardiotoxicity
AU - Kothai, Ramalingam AU - Thambi, Smitha AU - Arul, Balasubramanian 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 12
SP  - 792
EP  - 797
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.12.792.797
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.12.792.797
KW  - Doxorubicin
KW  - cardiotoxicity
KW  - oxidative stress
KW  - apoptosis
KW  - AMPK
KW  - cardioprotection
AB  - Doxorubicin (DOX) is an effective chemotherapeutic agent used to treat
colorful cancers but is limited by its cure‐dependent cardiotoxicity. This
review discusses the crucial mechanisms involved in DOX‐ convinced
cardiac damage, including oxidative stress, intracellular calcium
dysregulation, mitochondrial dysfunction, AMPK signaling inhibition,
apoptosis, and bloodied autophagy. Clinical instantiations range from
subclinical changes to heart failure, with early signs similar as reduced left
ventricular ejection bit and increased cardiac biomarkers. Several
pharmacological and natural agents including dexrazoxane, metformin,
statins, sildenafil, vitamin E, and curcumin have shown cardioprotective
goods by targeting these pathways. Understanding these mechanisms
and treatments is essential to reduce cardiovascular pitfalls and
ameliorate patient issues during DOX‐ grounded chemotherapy.
ER  -