TY  - JOUR
T1  - Oral Misoprostol vs Oxytocin: A Comparative Study in Induction of Labour in Prelabour Rupture of membrane
AU - Inukollu, Pranadeep AU - Bhuvaneswari, L. 
JO  - Research Journal of Medical Sciences
VL  - 18
IS  - 11
SP  - 677
EP  - 680
PY  - 2024
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2024.11.677.680
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2024.11.677.680
KW  - Prelabor rupture of membranes
KW  - PROM
KW  - induction of labor
KW  - oral misoprostol
KW  - intravenous oxytocin
KW  - maternal outcomes
KW  - neonatal outcomes
KW  - randomized controlled trial
AB  - Prelabor Rupture of Membranes (PROM) at term poses significant clinical
challenges, often necessitating timely induction of labor to reduce
maternal and neonatal risks. This study compares the efficacy and safety
of oral misoprostol versus intravenous oxytocin for labor induction in
women with PROM. The primary aim was to compare the induction-todelivery
interval and mode of delivery between oral misoprostol and
oxytocin. Secondary objectives included evaluating maternal and
neonatal outcomes associated with both methods. This randomized
controlled trial was conducted at Sree Mookambika Institute of Medical
Sciences, Tamil Nadu, from January to December 2024. A total of 152
term pregnant women with PROM were randomly assigned to receive
either oral misoprostol (25 μg every 6 hours, up to 4 doses) or
intravenous oxytocin (titrated infusion). The primary outcome was the
induction-to-vaginal delivery interval. Secondary outcomes included
mode of delivery, maternal complications and neonatal outcomes. The
mean induction-to-delivery time was significantly longer in the
misoprostol group (10.15±5.66 hrs) compared to the oxytocin group
(7.75±2.90 hrs, p<0.001). Vaginal delivery rates were similar (misoprostol
82%, oxytocin 87%). Maternal complications, including pyrexia and
uterine hyperstimulation and neonatal outcomes such as Apgar scores
and NICU admissions showed no significant differences between groups.
Both oral misoprostol and intravenous oxytocin are effective and safe for
labor induction in PROM. Misoprostol is associated with a longer
induction-to-delivery interval but comparable maternal and neonatal
outcomes.
ER  -