TY  - JOUR
T1  - Anti-Hyperglycemic and Hypolipidemic Effect of Ethanolic Extract of <I>Chrysophyllum albidum</I> Seed Cotyledon in Alloxan Induced-Diabetic Rats
AU - , O.S. Olorunnisola AU - , S. Amao AU - , L.O. Ehigie AU - , A.F. Ajayi 
JO  - Research Journal of Applied Sciences
VL  - 3
IS  - 2
SP  - 123
EP  - 127
PY  - 2008
DA  - 2001/08/19
SN  - 1815-932x
DO  - rjasci.2008.123.127
UR  - https://makhillpublications.co/view-article.php?doi=rjasci.2008.123.127
KW  - Diabetes Mellitus
KW  -Chrysophyllum albidum seed cotyledon
KW  -alloxan
KW  -hyperglycaemic
KW  -lipid profile
AB  - The present study evaluate the anti-hyperglycemic and hypolipidemic effect of ethanolic extract prepared from <I>Chrysophyllum albidum</I> seed cotyledon in model of alloxan-induced diabetic rats. Results showed that the daily treatment of diabetic rats with ethanolic extract of <I>Chrysophyllum albidum</I> seed cotyledon twice daily for 7 days (100 and 200 mg kg <SUP>1</SUP> orally) significantly decreased (p&lt;0.001) the blood glucose levels by 11.92 and 12.10%, respectively in the treated induced diabetic rats compared to the diabetic control rats. The 100 mg kg <SUP>1</SUP> dose of the extract showed insignificant decrease in the hepatic lipids (except HDL-cholesterol) concentrations, while the 200 mg kg <SUP>1</SUP> of the extract showed a significant decrease (p&lt;0.001) in the hepatic lipids (except HDL-cholesterol) in the treated diabetic rats and treated non-diabetic rats. However, the various doses of the extract significantly increased (p&lt;0.001) the HDL-cholesterol in treated diabetic rats while, there was no significant effect on the hepatic HDL-cholesterol in the treated non-diabetic rats. The results justify the popular use of <I>Chrysophyllum albidum</I> seed cotyledon, pointing out to the potential benefit of the plant ethanolic extract in alternative medicine in the treatment of diabetes mellitus.
ER  -