TY  - JOUR
T1  - Influence of Avian Influenza Virus on Human Inflammatory Gene Expression Profile
AU - Thonnon Al-Ghazal, Abdulrhem 
JO  - Research Journal of Biological Sciences
VL  - 14
IS  - 1
SP  - 1
EP  - 6
PY  - 2019
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2019.1.6
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2019.1.6
KW  - H5N1
KW  -gene expression
KW  -RT-PCR-array
KW  -cytokines
KW  -white blood
KW  -inflammatory
KW  -mortality
AB  - Avian influenza A/H5N1 virus considered as a public health risk with systemic inflammatory response
syndrome. Outbreaks in poultry usually cause transmission to human by the ora fecal route leading to high rate
of morbidity or mortality. Avian influenza A/H5N1 virus stimulates gene expression of immune inflammatory
host genes which cause high pathogenic impact on human. From 90 patients suffer from severe respiratory
symptoms, only 6 patients were serologically diagnosed infected with avian influenza A/H5N1 virus.
Real-Time-Reverse Transcription PCR-array (RT-PCR-array) was used twice (first with acute samples and
second with control cycle) to determine the rate of immune-inflammatory gene expression (Gene fold change)
in human white blood cells. Our findings reveal that avian influenza virus H5N1 viruses can infect human white
blood cells resulting in the induction of 9 proinflammatory cytokines (CCL2, CCL3, CCL4, CCL5, CXCL9,
CXCL10, IFNa, IFNb and TNF). Our observations suggest that avian influenza H5N1 infection can trigger
profound white blood cell impact which may play an important role in the relationship between the
pathogenesis of avian influenza virus H5N1 and host immune.
ER  -