TY  - JOUR
T1  - Anti-α-Glucosidase, Anti-α-Amylase and Anti-Inflammatory Effects of
Leaf Extracts of <i>Ziziphus Spina-christi</i> (Sedr) Grown in Jordan
AU - M.J. Khaleel, Sabah 
JO  - Research Journal of Biological Sciences
VL  - 13
IS  - 1
SP  - 1
EP  - 7
PY  - 2018
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2018.1.7
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2018.1.7
KW  - Ziziphus spina-christi
KW  -anti-&alpha;-glucosidase
KW  -anti-&alpha;-amylase
KW  -anti inflammation
KW  -extract
KW  -diabetes
KW  -inflammation
AB  - <i>Ziziphus Spina-christi</i> is a famous plant in Jordan available in different regions. It is used traditionally
for the treatment of several pathologies. The aim of this study is to investigate and compare the <i>in vitro</i> &alpha;-glucosidase, &alpha;-amylase and inflammation inhibitory activities for different concentration of methanolic
and ethanolic leaf extracts of <i>Z. Spina-christi</i>. Fresh leaves of <i>Z. Spina-christi</i> were collected and
subjected to methanolic and ethanolic extraction and were investigated for their anti-&alpha;-glucosidase, anti-&alpha;-amylase and anti-inflammatory activities. Methanolic extract seems to be a strong potent in both
enzymes inhibitory potential compared to ethanolic. The calculated IC<sub>50</sub> were 8.9 and 305.6 &mu;g/ml against &alpha;-glucosidase activity and 39.12 and 318.4 &mu;g/ml against &alpha;-amylase activity for methanolic and
ethanolic leaf extracts, respectively. Anti-inflammatory activity, using protein denaturation method, showed
that methanolic extract exhibited a highest anti inflammatory effect compared with ethanolic extract and the
standard. At the concentration of 100 &mu;g/ml, the anti inflammatory effect were 95.3, 25.2 and 20.2% for
methanolic extract, ehanolic extract and standard diclofenac sodium, respectively. This study support and
agree with the traditional usage of plants of <i>Z. Spina-christi for the control of diabetes and inflammation.
ER  -