TY  - JOUR
T1  - Evaluation of the Genotoxic Effect of <I>Salvadora persica</I> on
Mice Bone Marrow Cells
AU - Moh’d Yousef Alshibly, Nasser 
JO  - Research Journal of Biological Sciences
VL  - 12
IS  - 1
SP  - 13
EP  - 19
PY  - 2017
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2017.13.19
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2017.13.19
KW  - sister chromatid
KW  -chromosomal aberrations
KW  -natural products
KW  -genotoxicity
KW  -Salvadora persica
KW  -exchanges
KW  -mice
AB  - The miswak is a typical toothbrush made from the branches of the Salvadora persica
(Salvadoraceae). In addition, to consolidation the gums, it inhibits tooth decay, eliminating toothaches and
break further increase in decay that has already set in. It creates a scent in the mouth, eliminates bad odor,
improves the sense of taste and causes the teeth to radiance and shine. The other portions of the tree have
therapeutic values as corrective, deobstruent, liver tonic, diuretic, analgesic, anthelmintic, astringent,
lithontriptic, carminative, diuretic, aphrodisiac and stomachic. The present review is therefore an effort to give
detailed survey of the literature on phytochemistry and pharmacological activities of miswak. Genotoxicity of
Salvadora persica was evaluated on mice bone marrow cells using cytogenetics and molecular biology markers.
Micronuclei in Polychromatic Erythrocytes (PCEs), Chromosome Aberrations (CAs) in bone-marrow and types
of damage in DNA with Comet assay were scored after treatment of mice with 0.325, 0.65 and 1.3 mg/kg BWT
for 5 successive days. The results showed significant increase in numbers of micronuclei, types of chromosome
aberration in bone-marrow cells in treated groups compared with control groups. In addition, significant
differences in levels of damage in DNA of both liver and bone-marrow cells in treated groups compared with
control groups. The study reveals that high doses of Salvadora persica induce features of genotoxicity in whit
mice. The researchers recommend that extreme supervision must be applied upon uncontrolled using of
Salvadora persica and the high doses must not be used except when highly needed.
ER  -