TY  - JOUR
T1  - Collagen-Calcium Alginate Film Dressing with Therapeutic Ultrasound to Treat Open Wound in Rats
AU - Khaled, M.A. AU - Jalila, A. AU - Kalthum, H. AU - Noordin, M. AU - Saleh, W. Asma 
JO  - Research Journal of Biological Sciences
VL  - 9
IS  - 2
SP  - 57
EP  - 61
PY  - 2014
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2014.57.61
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2014.57.61
KW  - Ultrasound
KW  -collagen
KW  -calcium alginate
KW  -wound
KW  -biomaterials
KW  -tissues
AB  - About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were 
  used in this study over a 20 day period. They were allocated randomly into 4 
  groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was 
  control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic 
  ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate 
  film with therapeutic ultrasound. On application, the collagen-calcium alginate 
  film with therapeutic ultrasound was well accepted by the animals without any 
  adverse reaction. Mean percentage of wound contraction were significantly better 
  in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium 
  alginate film with therapeutic ultrasound treated group as compared to the other 
  groups. Collagen is a biocompatible protein that does not interfere with the 
  body’s normal immunologic response and can be used in non-healing chronic 
  wounds which require a trigger to stimulate the normal healing process. In extensive 
  wounds when there is lack of autologous tissue, biomaterials like collagen-calcium 
  alginate may be beneficial and can be used.
ER  -