TY  - JOUR
T1  - Hepatotoxicity of Imidacloprid in Male Rabbit: Physiological and Histological 
  Aspects
AU - Z.Al. Agha, Salam AU - M. Yassin, Maged AU - E. Esleem, Naela 
JO  - Research Journal of Biological Sciences
VL  - 9
IS  - 1
SP  - 24
EP  - 33
PY  - 2014
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2014.24.33
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2014.24.33
KW  - Imidacloprid
KW  -toxicity
KW  -live
KW  -physiology
KW  -histology
KW  -male rabbits
AB  - The present study was aimed to investigate the histopathological and physiological alterations in the liver of male rabbit in response to imidacloprid administration. Rabbits were given orally the dose of 1/10 LD<SUB>50</SUB> imidacloprid daily (mg/100/L) for 8 weeks. Control animals were given distilled water. Upon imidacloprid administration, alanine amino transferase generally showed significant increase throughout the experimental periods with maximum increase in the 2nd and 5th weeks compared to controls (70.8&plusmn;4.1 v 52.0&plusmn;3.0 and 65.3&plusmn;3.9 v 49.8&plusmn;3.0; % difference = 36.2 and 31.1; p = 0.017 and 0.020, respectively). Aspartate amino transferase was also increased with significant changes at the 3rd, 4th and 5th weeks (49.2&plusmn;3.0 v 35.7&plusmn;2.1; 43.2&plusmn;2.7 v 34.8&plusmn;1.5 and 43.0&plusmn;2.1 v 36.1&plusmn;1.7; % difference = 37.8, 24.1 and 19.1; p = 0.012, 0.031 and 0.047). Alkaline phosphates increased in the first 4 weeks showing maximum increase during the 2nd week compared to controls (129.5&plusmn;6.3 v 103.3&plusmn;3.9, % difference = 25.4, p = 0.012). In the last 4 weeks, the enzyme activity decreased with maximum decrease at the 6th week (83.3&plusmn;.5 v 107.8&plusmn;5.7, % difference = 22.7, p = 0.018). Similar changed were observed for cholinesterase with maximum increase at the 4th week (6167&plusmn;235 v 4624&plusmn;168, % difference = 33.4, p = 0.002) and maximum decrease at the 8th week (3831&plusmn;233 v 4876&plusmn;155, % difference = 21.4, p = 0.011.
ER  -