TY  - JOUR
T1  - The Role of Heat Shock Protein 90 in Human Reproduction
AU - Hamadneh, Jehan AU - Alkhatib, Ahed Jumah AU - Bjorklund, Geir AU - Alrasheidi, Saleh A. AU - Hamadneh, Shereen AU - Banihani, Mahmoud AU - Raffee, Liqaa A. AU - Alawneh, Khaled Zayed 
JO  - Research Journal of Biological Sciences
VL  - 9
IS  - 5
SP  - 161
EP  - 164
PY  - 2014
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2014.161.164
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2014.161.164
KW  - Hsp90
KW  -chaperones
KW  -infertility
KW  -autoimmune disease
KW  -POI
KW  -POF
AB  - The aim of this study is to give a review of the current knowledge about the Heat shock protein 90 (Hsp90) and its relation with human reproduction. Hsp90 is a chaperone and conserved protein. It accounts for about 1-2% of total proteins. There are 2 isoforms of Hsp90: Hsp90α and β. The contribution of Hsp90 isoforms to various cellular processes including signal transduction, protein folding, protein degradation, cell survival and morphological evolution has gained high interest. The idea of considering infertility as an autoimmune disease is exciting. Various studies have demonstrated antiovary antibodies against Hsp90. In this study, such concepts and their implications have been reviewed.
ER  -