TY  - JOUR
T1  - Antibacterial and Cytotoxic Activities of Four Red Sea Soft Corals from Gulf of Aqaba-Jordan
AU - Al-Zereini, Wael A. 
JO  - Research Journal of Biological Sciences
VL  - 9
IS  - 4
SP  - 122
EP  - 128
PY  - 2014
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2014.122.128
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2014.122.128
KW  - Red Sea
KW  -cytotoxicity
KW  -antimicrobial
KW  -oft coral
KW  -Gulf of Aqaba
KW  -Jordan
AB  - About 40% of worldwide identified soft corals are native to the Red Sea. They represent a source of compounds with potential pharmaceutical applications. Soft coral samples collected from Jordanian coast of Gulf of Aqaba were identified morphologically and anatomically and found to be <I>Sinularia polydactyla</I>, <I>S. grayi</I>, <I>S. copressa </I>and <I>Sarcophyton </I>sp. They were extracted with ethyl acetate and the resulting crude extracts were partially purified on lsilica gel column producing fractions with antimicrobial and/or cytotoxic activities. Gram positive <I>Bacillus subtilis </I>was the only inhibited test bacterial strain and Jurkat was the most affected cell line. Crude extract of <I>S. compressa </I>contains the most potent antibacterial compounds with MIC (8-62.5 &#956;g mL<SUP>-1</SUP>) and antitumor metabolites with IC (10-30 &#956;g mL<SUP>-1</SUP>). These activities are due to presence of 50 compounds with different polarities.
ER  -