TY  - JOUR
T1  - Association of Human Papillomavirus Type 6 and 11 with Head and Neck Squamous Cell Carcinomas in Sudanese Patients
AU - Osman, Hind El Rayah AU - Bareer, Ebtihal Hashim AU - Elmalaika, Nazik AU - Husain, Obaid Seid Ahmed 
JO  - Research Journal of Biological Sciences
VL  - 8
IS  - 5
SP  - 174
EP  - 178
PY  - 2013
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2013.174.178
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2013.174.178
KW  - HPV genotypes
KW  -male
KW  -female
KW  -infection
KW  -Statistics Package of Social Sciences (SPSS)
AB  - The aim of this study was to know the relation between HPV 
  type 6 and 11 and the head and neck squamous cell carcinomas in Sudanese patients 
  and to study the histopathology of those neoplasms. About 59 HNSCCs samples, 
  including 28 previously HPV type 16 negative extracted DNA samples and 31 formalin 
  fixed paraffin-embedded tissues were used for conventional polymerase chain 
  reaction to detect HPV type 6 and 11. Statistics Package of Social Sciences 
  (SPSS) was used to analyze the data. In those biopsies, there were 34 male squamous 
  cell carcinomas (58%) and 25 female squamous cell carcinomas (42%). DNA of HPV 
  type 6 and 11 was each detected in about 25% of the examined samples. The DNA 
  samples that were HPV type 16 negative revealed 14 positive samples for HPV 
  type 6 and total absence of HPV type 11. The age category 41-50 years was found 
  to be the most affected age category with HNSCC in both genders. It constituted 
  27% of HPV type 6 positive samples and 13% of HPV type 11 positive samples. 
  The most frequent site for HNSCC is the nasopharynx that constituted about 64% 
  (38 sample) of the total examined samples, 53% of the HPV type 6 and 27% HPV 
  type 11 positive samples were from that site. Most of positive samples for HPV 
  type 6 were poorly differentiated. Most of positive samples for HPV type 11 
  were well differentiated. Most of positive samples for HPV type 6 were non-keratinized 
  (60%) whereas 60% of HPV type 11 were keratinized. The relation between HPV 
  type 6 and 11 and the gender age site of SCC, differentiation and keratinisation 
  was found to be insignificant. Further studies are needed investigate the relation 
  between HPV genotypes (HPV type 6, 11 and 16) to probably induce multiple infection 
  required for the development of malignant lesions.
ER  -