TY  - JOUR
T1  - Lipid Lowering Activity of <I>Moringa pergerina</I> Seeds in Rat: A Comparison Between the Extract and Atorvastatin
AU - Rouhi-Broujeni, Hojjat AU - Heidarian, Esfandiar AU - Darvishzadeh-Boroojeni, Pariya AU - Rafieian-Kopaei, Mahmoud AU - Gharipour, Mojgan 
JO  - Research Journal of Biological Sciences
VL  - 8
IS  - 5
SP  - 150
EP  - 154
PY  - 2013
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2013.150.154
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2013.150.154
KW  - Cardiovascular
KW  -hypercholosterolemia
KW  -Moringa peregrina
KW  -hyperlipidemia
KW  -oxidative stress
AB  - Hyperlipidemia is the most important cardiovascular risk factor. 
  <I>Moringa peregrina</I> is traditionally used as antihyperglycemia and antihyperlipidemia. 
  This study aimed to investigate, the effects of hydroalcoholic extract of <I>Moringa 
  peregrina</I> on lipid profile and atherogenic biomarkers of hyperlipidemic 
  rat. In this experimental study, 40 male Wistar rats were divided into four 
  equal groups: Normal rats, high fat diet rats (hyperlipidemia induced with persintra-M) 
  high fat diet with <I>Moringa peregrina</I>, high fat diet plus atorvastatin. 
  The regimens were given orally (by gavage) for 40 days. Also, serum lipid profile, 
  thiol level, Malondyaldehide (MDA), antioxidant capacity, ferritin, CRP as well 
  as atherogenic index were determined. Treatment with <I>Moringa peregrina</I> 
  seeds significantly decreased serum LDL, VLDL, trigeliceride and total cholesterol 
  and increased HDL-C. The Atherogenic index decreased. Also, MDA, ferritin and 
  CRP were reduced and plasma thiol level icreased. The data demonstrates that 
  the leaves ethanolic extract of <I>Morninga peregrina</I> has antioxidant activity 
  and antilipidemic effect on hyperlipidemic rats. Also, reduction of lipid and 
  protein peroxidation as an index of oxidative stress is evident.
ER  -