TY  - JOUR
T1  - Toxicological Evaluation of <i>Thermoascus aurantiacus</i> Sl16W in Albino Rats: Subchronic Toxicity Study
AU - Kongbuntad, Watee AU - Saenphet, Kanokporn AU - Wongputtisin, Pairote AU - Khanongnuch, Chatchai AU - Lumyong, Saisamorn 
JO  - Research Journal of Biological Sciences
VL  - 7
IS  - 6
SP  - 240
EP  - 243
PY  - 2012
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2012.240.243
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2012.240.243
KW  - Thermoascus aurantiacus
KW  -xylanase
KW  -subchronic toxicity
KW  -toxicity test
KW  -enzyme
KW  -Thailand
AB  - The purpose of this study was to evaluate the toxicology of 
  crude xylanase enzymes prepared from <I>T. aurantiacus </I>SL16W in male Albino 
  rats. Sixty rats aged 6 weeks old were randomly distributed into 4 groups of 
  15 rats. The 1st group was the untreated control while the 2nd (400 U), 3rd 
  (2000 U) and 4th (4000 U) groups received the crude xylanase enzyme at dose 
  levels of 400, 2000 and 4000 unit/kg body weight/day, respectively. After treatmemt 
  body weight, organ weight, hematology and plasma chemistry were examined. The 
  results indicated that oral force-feeding of the crude xylanase enzyme did not 
  affect the body and organ weight of the rats. Hemoglobin values in the 2000 
  U group and hematocrit values in the 2000 U group were slightly decreased compared 
  to the control group. The levels of Blood Urea Nitrogen (BUN), creatinine, aspartate 
  Aminotransferase (AST) and alanine Aminotransferase (ALP) were not significantly 
  different between the groups except that the ALT of the 200 U was significantly 
  lower than the control group.
ER  -