TY  - JOUR
T1  - Effects of Haruan (<I>Channa striatus</I>) Based Cream on Acute Inflammation 
  in Croton Oil Induced Mice Ear Edema Model
AU - Abedi, Sadegh AU - Ehtesham Far, Fatemeh AU - Khairi Hussain, Mohd. AU - Ahmad, Zuraini AU - Manan Mat Jais, Abdul 
JO  - Research Journal of Biological Sciences
VL  - 7
IS  - 4
SP  - 181
EP  - 187
PY  - 2012
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2012.181.187
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2012.181.187
KW  - Haruan (Channa striatus)
KW  -Haruan based cream
KW  -acute inflammation
KW  -croton oil
KW  -Myeloperoxidase (MPO)
AB  - Inflammation is a non-specific reaction of body tissues against harmful stimulus, injury or infection to protect the body and promote the recovery process. Myeloperoxidase a pro-inflammatory enzyme released by activated neutrophils and macrophages is frequently used as a marker of polymorphonuclears accumulation in different tissue samples. Haruan (<I>Channa striatus</I>) is a tropical, snakehead, freshwater, air breathing and carnivorous fish belongs to family channadae which is indigenous to Malaysia. The current study was undertaken to identify the properties of a new haruan based cream as a natural product on myeloperoxidase enzyme as a marker of polymorphonuclears accumulation. In the present study, anti-inflammatory activity of haruan (<I>Channa striatus</I>) based cream (at doses 1, 5 and 10%) on the ear thickness and myeloperoxidase activity (as two acute inflammation indexes) were studied using croton oil induced ear edema method and compared with effects of hydrocortisone 1% cream as reference drug. Results showed that all percentages of haruan based cream in a same potent with reference treatment significantly inhibited edema at 4 and 24 h after croton oil application (p&lt;0.05). Besides, myeloperoxidase assay results shown that topical application of these three different dosages of haruan based cream also block migration of polymorphonuclear leukocytes to the dermis as effective as hydrocortisone cream 1% and in a dose dependent manner (p&lt;0.05). Evidences obtained from the present study, on the one side, support the previous results that had shown the anti-inflammatory effects of haruan extracts in other animal models and on the other side, introduce a new topical biomedical product with a potency as great as hydrocortisone in inhibition of inflammation. It is suggested that topical anti-inflammatory effects of haruan based cream is contributed to its bioactive substances content such as linoleic acid, stearic acid, oleic acid and N-arachidonylplycine.
ER  -