TY - JOUR T1 - Effects of Hyoscine on First Stage of Labor in Full Term Pregnancy AU - Ghaleh, Talaat Dabaghi AU - Movahed, Faride AU - Lalooha, Fatemeh AU - Aziziyan, Samaneh AU - Mashrabi, Omid JO - Research Journal of Biological Sciences VL - 6 IS - 12 SP - 648 EP - 651 PY - 2011 DA - 2001/08/19 SN - 1815-8846 DO - rjbsci.2011.648.651 UR - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.648.651 KW - Hyoscine KW -1st stage of labor KW -APGAR scores KW -butyl bromide KW -pregnancy KW -Iran AB - This study was done in order to study the effect of IV injection of hyoscine upon delivery progression. This double blinded clinical trial study was done on 140 term, cephalic presentation pregnant women who have not natural vaginal delivery were admitted in Kosar hospital in autumn 1388 for pregnancy termination. A sample was selected based on inclusion and exclusion criteria and randomized divided into two groups, 20 mg (l mL) hyoscine was given to group one and l mL distilled water was given to control group (group 2). These IV injections were done as single dose at the beginning of active labor. After that duration of the 1st, 2nd and 3rd stages of labor, maternal complications and caesarean section rate during labor and APGAR scores in the neonates were recorded. Then data was analysis by Chi-square (χ2) and t-test. The mean time for the 1st stage in the control group was 113.5±47.2 min, compared with 100.64±48.3 min in the hyoscine group that was statistically significant (p = 0.045). There was no significant change in the duration of the 2nd and 3rd stages of labor and no difference in APGAR scores noted at 1 and 5 min, there was a slight (but statistically insignificant) increase in the caesarean section rate. No adverse effect was noted in the group of women receiving hyoscine, compared with the control group. Hyoscine butyl bromide is effective in significantly reducing the duration of the 1st stage of labor and it is not associated with any obvious adverse outcomes in mother or neonate. ER -