TY  - JOUR
T1  - Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives
AU - Singhal, Manmohan AU - Paul, Arindam 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 12
SP  - 632
EP  - 634
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.632.634
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.632.634
KW  - Anti-fungal
KW  -semicarbazones
KW  -chalcone
KW  -disk diffusion
KW  -lipophilic site
KW  -India
AB  - In the present study, researchers designed a Pharmacophore Model chalconesemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site, etc., using Ligandscout-2.02 software. A series of chalcone semicarbazones was synthesized and evaluated for their anti-fungal activity by Paper Disk Diffusion Method. Based on the results of an anti-fungal study, compound CS-10 was the most active compound. It was observed that methoxy substitution in aldehydic moiety and hydroxyl substitution in the acetophenic moiety significantly increased anti-microbial spectrum against fungi.
ER  -