TY  - JOUR
T1  - Therapeutic Efficacy  and <I>in vivo Giardia lamblia</I> Morphological Alterations Induced by Some Natural Medicinals
AU - M. Sanad, Magda AU - J. Al-Ghabban, Areej 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 6
SP  - 263
EP  - 271
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.263.271
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.263.271
KW  - Giardia lamblia
KW  -garlic
KW  -wheat germ agglutinin
KW  -selenium
KW  -metronidazole
KW  -therapeutic efficacy
KW  -Giardia lamblia ultrastructure
AB  - <I>Giardia lamblia</I>, the causative agent of giardiasis is a protozoan intestinal flagellate that infects humans, specially children allover the world. The current therapeutic agents have considerable adverse effects or be contraindicated in certain clinical situations or show failure due to drug resistance. Using a Mouse Model, the intent of the present study was to evaluate the <I>in vivo</I> therapeutic efficacy of garlic plant, wheat germ agglutinin WGA and selenium in comparison with meteronidazole and to declare their impact on ultrastructure of luminal trophozoites. The patent period, intensity of infection, cyst shedding and cure rate in groups treated by the natural therapeutics revealed a highly significant difference in comparison with the non-treated control and insignificant difference in comparison with metronidazole, a finding that might be beneficial at least in clinical situations where current chemotherapy is contraindicated. All of the tested therapeutics proved to be injurious to the parasite with evident morphological changes. While garlic appeared to induce changes that interfere with the progress of trophozoite motility, selenium and WGA seemed to be evidently lethal to the parasite.
ER  -