TY  - JOUR
T1  - Sequence Analysis of Txk from the Scorpion <I>Mesobuthus eupeus</I> Venom Glands Using Semi-Nested RT-PCR
AU - Eskandari, Ghafar AU - Jolodar, Abbas AU - Moghadam, Ahmad Taghavi 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 1
SP  - 12
EP  - 14
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.12.14
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.12.14
KW  - amino acid
KW  -Armenia
KW  -scorpion venom
KW  -K+ channels
KW  -beta neurotoxin
KW  -Sequence analysis
AB  - Natural toxins are useful probes for evaluating the involvement of K+ channels in cell activity and for investigating K+ channel structure and localization. In recent years, peptide toxins that block various K+ channels with high affinity have been purified from diverse animal venoms. One polypeptide beta neurotoxin named Txk was isolated from the venom of scorpion <I>Mesobuthus eupeus</I> of Khuzestan. This toxin consists of 91 amino acid residues which modulate voltage-gated sodium channels gating. In this study, cDNA of Txk &beta;-toxin was amplified and sequence of beta neurotoxin compared with <I>M</I>. <I>martensii occitanus Israelis</I> and <I>Tityus costatus</I> however, the comparison suggests that the length of the peptide is close to the long-chain potassium ion channel blocker peptide family.
ER  -