TY  - JOUR
T1  - Anti Inflammatory Effect of Grape Seed (<I>Vitis vinifera</I>) Extract on Formalin-Induced Edema in Rat Paw
AU - Ali Asghar, Hemmati AU - Ardeshir, Arzi AU - Pari, Tamri 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 12
SP  - 760
EP  - 763
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.760.763
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.760.763
KW  - Grape seed
KW  -inflammation
KW  -rat paw edema
KW  -Vitis vinifera
KW  -injection
KW  -Iran
AB  - Several studies have shown that grape seed extract possess anti-inflammatory effect because of its components such as procyanidine. The purpose of this study was the investigation of the anti-inflammatory effect of grape seed extract on formalin-induced edema in rat paw. Hydroalcohlic extract of grape seed (<I>Vitis vinifera</I>) was prepared using maceration method. Albino rats weighting 180-200 g were divided in to 5 groups as intraperitoneal GSE receiving (200, 400 and 600 mg kg<SUP>-1</SUP>), positive control (indomethacin 5 mg kg<SUP>-1</SUP> p.o.) and negative control (normal saline 5 mg kg<SUP>-1</SUP> IP), 30 min following IP injection of GSE or indomethacin administration 0.1 mL of formalin (2.5% w/v) was injected in rat hind paw and the changes in rat's paw volume was assessed by plethysmometer for 3 h at intervals of 1 h. Grape seed extract (200, 400 and 600 mg kg<SUP>-1</SUP>, IP) exerted anti-inflammatory effect in a dose dependent manner. Hydroalcoholic seed extract in dose of 600 mg kg<SUP>-1</SUP> was more effective against formalin-induced paw inflammation. However, this effect was less potent than indomethacin (5 mg kg<SUP>-1</SUP>) effect as positive control.
ER  -