TY  - JOUR
T1  - Central Injections of β-Endorphin Fragment Modulate theAnorexia by Insulin in Neonatal Chicks
AU - Bungo, Takashi AU - Yanagita, Kouchi AU - Shiraishi, Jun-ichi 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 1
SP  - 64
EP  - 67
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.64.67
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.64.67
KW  - insulin
KW  -fragment
KW  -²-endorphin
KW  -Feed intake
KW  -central nervous system
KW  -chick
AB  - Recently, researchers found that β-endorphin regulates the activity of the central melanocortin system and its activation provides an inhibitory feedback mechanism in the brain of neonatal chicks. It is known that fragments of β-endorphin have biological activities. Thus, the present study was done to elucidate whether N- or C-terminal of β-endorphin fragment affects the insulin-induced anorexia in chicks. Researchers found that intracerebroventricular injection of insulin with N-terminal fragment, β-endorphin-(1-27), accelerated the insulin-induced hypophagia in neonatal chicks during the 60 min period postinjection. Conversely, the anorexic effect of insulin was attenuated by C-terminal fragment, β-endorphin-(30-31). These data suggest that both fragments involve in the regulation of feeding behavior and they may modulate the activity of the central melanocortin system in the brain of neonatal chicks.
ER  -