TY  - JOUR
T1  - The Hydro-Alcoholic Extract of Pomegranate Seed Has Anti-Inflammatory Effects on Formalin-Induced Inflammation in Rat Hind Paw
AU - Mikaili, Peyman AU - Hemmati, Ali Asghar AU - Arzi, Ardeshir AU - Karampour Sistani, Neda 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 8
SP  - 561
EP  - 564
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.561.564
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.561.564
KW  - formalin
KW  -rat paw edema
KW  -anti-inflammatory
KW  -Pomegranate seed
KW  -indomethacin
KW  -Iran
AB  - Several <I>in vivo</I> studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms. In the present study, the anti-inflammatory properties of total hydro-alcoholic extract isolated from pomegranate seed were investigated in formalin-induced rat paw edema. The studied male Wistar albino rats (n = 30) were divided into 5 groups. Inflammation was created by injection of formalin (2.5%) intraplantarily. Then different doses of extract (100, 200, 400 mg kg<SUP>-1</SUP>) were injected in 3 groups, indomethacin (5 mg kg<SUP>-1</SUP>) was injected in 4th group and control group received 5 mL of normal saline intraperitoneally. About 1-3 h after injection of the extract, indomethacin and saline, the volume of paw was measured in all groups by plethysmometer. The results showed hydro-alcoholic extract of pomegranate seed has dose-dependent anti-inflammatory effect and the highest anti-inflammatory effect was observed in the dose of 400 mg kg<SUP>-1</SUP>.
ER  -