TY  - JOUR
T1  - DNA Damage Induced in the Germ and Bone Marrow Cells of Mice by Caffeine
AU - Utulu, Sylvia AU - Bakare, Adekunle A. 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 8
SP  - 536
EP  - 541
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.536.541
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.536.541
KW  - Caffeine
KW  -genotoxicity
KW  -mice
KW  -micronucleus
KW  -spermatozoa
KW  -health risk
KW  -saline
AB  - Caffeine is a major constituent of many drugs and also widely and immensely consumed in beverages and soft drinks. The public health implication of the habitual and indiscriminate consumption of caffeine containing products has prompted studies on its safety evaluation. In this study, we investigated the potentials of caffeine to induce abnormal sperm cells in the testes and Micronuclei (MN) in the bone marrow cells using the sperm morphology and MN assays in mice. For these assays, mice were administered Intraperitoneally (IP) caffeine at dose levels of 0.39, 0.78, 1.56 and 3.12 mg kg<SUP>-1</SUP> bwt (body weight) and normal saline and cyclophosphamide were used as negative and positive controls, respectively.</P>
ER  -