TY  - JOUR
T1  - <I>In vitro</I> Antifungal Activity of <I>Senna alata </I>Linn. Crude Leaf Extract
AU - Adewale, O.G. AU - Alli, J.A. AU - Nwanze, J.C. AU - Ojezele, M.O. AU - Okonko, I.O. AU - Joseph, T.A. AU - Ojezele, O.J. AU - Sule, W.F. 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 3
SP  - 275
EP  - 284
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.275.284
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.275.284
KW  - Antifungal activity
KW  -biochemical components
KW  -crude extract
KW  -dermatophytes
KW  -Phytoconstituents
KW  -Senna alata L.
KW  -MIC
AB  - This study reports on the <I>in vitro </I>antifungal activity of <I>Senna alata</I> Linn. crude leaf extract on clinical test Dermatophytes. The studies on the <I>in vitro</I> investigation of antifungal activities of ethanolic extracts of <I>Senna alata </I>L. leaf was carried out. The test was conducted on Dermatophytes which included Dermatophytes of the genera <I>Trichophyton</I>,<I> Microsporum </I>and <I>Epidermophyton</I>. These fungi are the causative agents of various types of dermatophytosis which attack various parts of the body and tend to the following conditions, <I>Tinea capitis, Tinea cruris, Tinea coporis </I>and <I>Tinea pedis</I>. The results obtained showed that the leaf exudates and the ethanol extract of the leaf of <I>Senna alata </I>L. exhil: had marked antifungal effects on <I>Microsporum canis</I>,<I> Trichophyton jirrucosum</I>,<I> Trichophyton mentagrophytes</I> and <I>Epidermophyton jlorrcosum</I>. The ethanolic extract showed the highest inhibition on <I>trinchophyton verrucosuf</I> and <I>Epidermophyton jloccosum </I>with 20.50 and 20.00 mm zone of inhibition, respectively. The Minimum Inhibitory Concentration (MIC) was also performed and the result showed that the MIC of <I>Senna alata </I>L. on all the tested Dermatophytes was 5.0 mg mL<SUP>-1</SUP> which is the standard. The results obtain from the biochemical analysis of the plant <I>Senna alata </I>L. revealed the presence of Alkaloids, Saponins, Tannins, anthracionones and carbohydrates.
ER  -