TY  - JOUR
T1  - <I>In vitro</I> Evaluation of Hydroxyl and Nitric Oxide Radical Scavenging Activities of Artemether
AU - O. Ehigie, L. AU - S. Adekunle, A. AU - T Olaleye, M. AU - O. Odedire, O. AU - M. Olabinri, B. AU - F. Olabinri, P. 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 1
SP  - 102
EP  - 105
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.102.105
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.102.105
KW  - in vitro
KW  -Artemisinins
KW  -pathophysiology
KW  -Free radical
KW  -reactive oxygen and nitrosative stress
KW  -Nigeria
AB  - The hydroxyl and nitric oxide radical scavenging activities and total phenolic content of artemether were investigated <I>in vitro</I>. The concentrations of artemether (200-1000 &#956;g mL<SUP>-1</SUP>) did not exhibit hydroxyl radical scavenging activity except at 200 &#956;g mL<SUP>-1</SUP> concentration. The mean values for the hydroxyl radical scavenging for the different concentration (200, 400, 600, 800 and 1000 &#956;g mL<SUP>-1</SUP>) of artemether were 47.55&plusmn;11.28, -3.49&plusmn;13.16, -30.09&plusmn;6.09, -34.74&plusmn;4.29 and -49.00&plusmn;7.75%, respectively. The total phenolic content of artemether in ethylacetate ranged from 208.00&plusmn;48.33 (SD) to 340.00&plusmn;14.14 &#956;g mL<SUP>-1</SUP>, while the total phenolic content of artemether in methanol ranged from 90.00&plusmn;6.3 (SD) to 122.00&plusmn;35.44 &#956;g mL<SUP>-1</SUP>. Total phenolic content of artemether was significantly higher in ethyl acetate than in methanol at all concentration investigated (p&lt;0.05). The total phenolic content arthemeter was influenced by the organic solvent used as a medium for preparing artemether.
ER  -