TY  - JOUR
T1  - Anticariogenic Effect of Amorphous Calcium Phosphate Stabilized by Casein Phosphopeptid: A Review Article
AU - , M. Moezizadeh AU - , S. Moayedi 
JO  - Research Journal of Biological Sciences
VL  - 4
IS  - 1
SP  - 132
EP  - 136
PY  - 2009
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2009.132.136
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2009.132.136
KW  - Milk
KW  -CPP
KW  -ACP
KW  -anticariogenic
KW  -enamel remineralization
AB  - The anticariogenic potential of casein phosphopeptid-amorphous calcium phosphate nanocomplexes (CPP-ACP) has been demonstrated using laboratory, animal and human <I>in situ</I> caries model. The CPP-ACP has also been shown to remineralize enamel subsurface lesions <I>in vitro</I> and <I>in situ</I> when delivered in sugar-free gum. The proposed anticariogenic mechanism for CPP-ACP is the localization of ACP at the tooth surface which buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel reducing demineralization and enhancing remineralization. The CPP-ACP therefore has exciting potential for use in oral care products and foods to help prevent dental caries and repair early stages of diseases, a development which will add significantly to dentists armoury of tools in preventive dentistry. This review article presents a brief on mechanism of action and role of CPP-ACP in caries prevention, remineralization of enamel lesions by CPP-ACP and use of CPP-ACP in different dental products like glass ionomer cement, tooth paste, mouth wash, tooth mousse and etc.
ER  -