TY  - JOUR
T1  - Antidiabetic Effect of <I>Otostegia persica</I> Oral Extract on Streptozotocin-Diabetic Rats
AU - Ebrahimpoor, M.R. AU - Khaksar, Z. AU - Noorafshan, A. 
JO  - Research Journal of Biological Sciences
VL  - 4
IS  - 12
SP  - 1227
EP  - 1229
PY  - 2009
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2009.1227.1229
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2009.1227.1229
KW  - Antidiabetic effect
KW  -Otostegia persica
KW  -stereptozotocin
KW  -blood glucose level
KW  -rats
KW  -Iran
AB  - Antidiabetic effect of the alcoholic extract of <I>Otostegia persica</I> was investigated on 40 streptozotocin diabetic rats in four equal groups. Animals in first group did not receive any extract and were as a control for other groups. Rats in group II, III and IV received 200, 350 and 500 mg kg<SUP>-1</SUP> daily administration of <I>Otostegia persica</I> oral extract, respectively for three weeks. Blood glucose level was estimated three times a day (8:00, 11:00 A.M and 5:30 P:M) in all groups. Statistical analysis of the results by t-test showed that the extract produced a dose-dependent decrease in the blood glucose level especially in fourth group (p&lt;0.0001) in comparison with first group. Thus, study indicate that <I>Otostegia persica</I> has a strong antidiabetic action and can decrease the blood glucose level.
ER  -