TY  - JOUR
T1  - Helicobacter pylori vac A Genotypes in Shahrekordian (Iran) <I>H. pylori</I>-Positive Patients
AU - , Abbas Doosti AU - , Pooria Ghasemi-Dehkordi 
JO  - Research Journal of Biological Sciences
VL  - 4
IS  - 1
SP  - 11
EP  - 15
PY  - 2009
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2009.11.15
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2009.11.15
KW  - Helicobacter pylori
KW  -genotype
KW  -vacA
AB  - Clinical outcome of <I>Helicobacter pylori</I> infection might be associated with specific virulence-associated bacterial genotypes. The distribution of different bacterial genotypes varies geographically. The aim of this study, is based on determining any associations between the <I>Helicobacter pylori</I> <I>vac</I>A research in causing gastritis and peptic ulcer, in Shahrekord, Iran. Gastric biopsies were collected from patients that were referred to endoscopy unit of Hajar hospital Shahrekord, Iran. <I>H. pylori</I> was detected in these biopsies by culture test. Then polymorphism of <I>vac</I>A gene was genotyped by Polymerase Chain Reaction (PCR). The <I>vac</I>A genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients. Also, the <I>vac</I>A s1 allele was more frequently identified than the <I>vac</I>A s2 allele among gastrointestinal patients. Furthermore, the severest genotype of <I>vac</I>A gene in these patients was s1/m2. The results of our study illustrated that s1/m2 genotypes were associated with peptic ulceration in patients that infected by <I>H. pylori</I>.
ER  -