TY  - JOUR
T1  - Correlation of Cyclooxygenase 2 (Cox-2) Presentation and Inflammatory Cells Infiltration in Colorectal Cancer: A Histopathological and Immunohistochemical Study
AU - , F. Naghshvar AU - , Z. Torabizadeh AU - , O. Emadian AU - , A. Khalilian AU - , I. Maleki AU - , K. Enami 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 8
SP  - 916
EP  - 918
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.916.918
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.916.918
KW  - Cerrical spine
KW  -traoma
KW  -surgical decompression
KW  -cancer
KW  -inflammatory cells
AB  - Colorectal cancer is the third most common cancer in the world and the second most common cause of cancer related death. Cox-2 has been reported to be significantly increased in up to 85% of human sporadic colorectal carcinoma. Little is known about interaction between Cox-2 and inflammatory cells of colorectal carcinoma. In all cases, archival H and E slides of the primary tumor were retrieved and reviewed to confirm pathological facture and to select suitable tissue blocks for Immunohistochemical analysis. The expression of Cox-2 was positive (grade 3-7) in 71.3% of tumors and associated with neutrophils, eosinophil, mast cell, macrophages and CD3+ lymphocytes (p = 0.001). Correlation of Cox-2 expression and CD8 lymphocytes was not significant (p = 0.569). The main purpose of this study was to evaluate the interaction between the Cox-2 expression and inflammatory cells. We showed that there is a close relationship of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages, lymphocyte (CD3+). The only exception was CD8 positive lymphocytes.
ER  -