TY  - JOUR
T1  - Atrial Natriuretic Factor Downregulation During Breast Cancer Progression
AU - , Biagio Valentino AU - , Giampiero La Rocca AU - , Rita Anzalone AU - , Simona Corrao AU - , Francesca Rappa AU - , Diego Lipari AU - , Alessandro Valentino AU - , Giovanni Peri AU - , Francesco Cappello AU - , Elvira Vittoria Farina-Lipari 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 2
SP  - 246
EP  - 250
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.246.250
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.246.250
KW  - Atrial natriuretic factor
KW  -oxytocin
KW  -breast cancer
KW  -carcinogenesis
AB  - We researched in a series of human breast cancers of different stages the presence and the expression of Atrial Natriuretic Factor (ANF) and Oxytocin (OX), by immunohistochemistry and RT-PCR. We found a reduction of expression of ANF during cancer progression. By contrast, OX resulted lightly expressed by immunohistochemistry and negative at RT-PCR. We hypothesize that ANF could be considered a novel marker to predict breast cancer progression; by contrast, OX expression should be better investigated, to clarify also the putative role of oxytocinases in human breast carcinogenesis.
ER  -