TY  - JOUR
T1  - Macrolides Antibiotics in Odontostomatological Practice: Past, Present and Future
AU - , G.A. Scardina AU - , A. Ruggieri AU - , F. Carini AU - , V. Valenza AU - , P. Messina 
JO  - Research Journal of Biological Sciences
VL  - 2
IS  - 6
SP  - 643
EP  - 649
PY  - 2007
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2007.643.649
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2007.643.649
KW  - Antibiotics
KW  -macrolides
KW  -efflux pumps
KW  -bacterial resistance
KW  -multidrug resistance
KW  -ketolides
KW  -telithromycin
AB  - Macrolides are considered the second choice in the odontostomatological practice especially in case of allergic reactions to the most important and well-known group of a-lactams. This group of antibiotics are more diffused in the daily practice of dentistry but during the time macrolides have shown a big potential in constant increasing. In this study, we report a review of the major features of these antibiotics which have become in the time farmacological choice effective and reliable versus bacterial infections supported by a-hemolytic streptococci, pneumococci, staphylococci, enterococci, mycoplasma, mycobacteria, some rickettsia and chlamydia. Furthermore, we refer about the recent researches that show the anti-inflammatory potentiality of the macrolides and the recent discoveries on the new pharmacological targets to exceed the problem of the bacterial resistance: the efflux pumps. Finally, we expose about a new class of antibiotic derived directly by the macrolides: Ketolides. They represent the future of the macrolides.
ER  -