TY  - JOUR
T1  - Detection of Caprine Arthritis Encephalitis Virus Gag-Gene by RT-PCR from Experimentally Infected Goat Brain Cells
AU - , I.A. Adebayo 
JO  - Research Journal of Biological Sciences
VL  - 2
IS  - 1
SP  - 25
EP  - 27
PY  - 2007
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2007.25.27
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2007.25.27
KW  - Caprine arthritis encephalitis
KW  -amplification
KW  -neurological dysfunctions
AB  - Different brain cell types obtained from goat cerebrum explant cultures were prepared from newborn goat kids and infected by direct Caprine Arthritis Encephalitis (CAE) virus application. Predominantly, cells of the monocyte-macrophage lineage were specifically infected by the virus as proviral DNA was detected in infected cultures by amplification of a 414 base-pair (bp) fragment of the viral gag-gene by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) technique. The present study revealed that microglia are the  target  brain  cells  infected  by  the CAE virus. This finding will undoubtedly help in devising some immuno-prophylactic measures to be adopted in the management of neurological dysfunctions resulting from retroviral infections of man (HIV) and animals.
ER  -