TY  - JOUR
T1  - Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena
AU - Buchachenko, Anatoly L. AU - Chekhonin, Vladimir P. AU - Orlov, Alexey P. AU - Kuznetsov, Dmitry A. 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 6
IS  - 3
SP  - 34
EP  - 37
PY  - 2010
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2010.34.37
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2010.34.37
KW  - Hyper activation of the ATP synthesis
KW  -magnetic isotope effects
KW  -mitochondria function control
KW  -phenomenon
KW  -Zn+2 ion
KW  -nuclei
AB  - The rate of enzymatic ATP synthesis is shown to depend on the zinc isotopes. The ATP producing activities of creatine kinase and pyruvate kinase in which Zn<SUP>2+</SUP> ions have magnetic nuclei <SUP>67</SUP>Zn are found to be 2-6 times higher than that of enzymes in which Zn<SUP>2+</SUP> ions have nonmagnetic nuclei <SUP>64</SUP>Zn. The isolated rat heart muscle mitochondria exhibit a similar effect. An expression of this magnetic isotope effect in enzymatic ATP synthesis processed in the presence of Zn<SUP>2+</SUP> ions is in a favor to the ion-radical mechanism of ATP production occurred within a high zinc concentration range. Both fundamental aspect and a possible pharmacological significance of the phenomenon described are under discussion.
ER  -