TY  - JOUR
T1  - Dysfunctional Lymphocyte Turnover in Subsequent Self-Generation of Autoimmunity
AU - , Lawrence, M. Agius 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 2
IS  - 1
SP  - 16
EP  - 22
PY  - 2006
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2006.16.22
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2006.16.22
KW  - Self genration
KW  -auoimmunity
KW  -dysfuntional
KW  -lymphocyte
AB  - Reactivity responses of autoimmune origin appear a realized series of pathways in the generation of dysfunctional versus homeostatic lymphocyte turnover.  Lymphocyte responsiveness would transform to a dysfunctional state in the generation of various subsets of cells as reflected in autoimmune phenomena. It is in terms of a dysfunctionality ranging in scope from primary generation of the lymphocyte subset to subsequent creation of a whole panorama of responsive influences and pathologic lesions that autoimmunity would evolve further as a self-generated reactivity in its own right.  Indeed, oligoclonality of antibody production in the cerebrospinal fluid of multiple sclerosis patients would arise as a phenomenon both primarily generated in terms of dysfunctional lymphocyte turnover and as a secondary process in the progression of such primary autoimmune reactivity exposing native myelin epitopes.
ER  -