TY  - JOUR
T1  - Ischemia as Superimposed Previous Ischemic Events Centered on Microcirculatory Failure
AU - , Lawrence M. Agius MD 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 1
IS  - 3
SP  - 294
EP  - 299
PY  - 2005
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2005.294.299
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2005.294.299
KW  - Ischemia
KW  -microcirculatory
KW  -vessels
KW  -injury
AB  - A clear delineation of events in the production of an ischemic lesion that evolves in terms of previous episodes of similar ischemia might implicate episodes of superimposition of various cellular injuries. Central to such events there would evolve a micro-circulatory failure that precipitates crescendo-type pathways of progressive injury to cells and also to vessels supplying the area concerned. It is perhaps with regard to such micro-circulatory events that evolve as regional and focally regional sites of injury to vessels that there would in turn become superimposed a proximal pathway of progressive luminal stenosis and occlusion of parent vessels such as the epicardial coronary arteries. One might indeed view superimposed episodes of ischemia to tissues and cells a source of propagated injury determining both microcirculatory failure and also an influence in progression of proximal vascular pathology related to impaired hemodynamics. Proximal parent vascular stenosis would progress hand in hand with microcirculatory failure in determining the acute critical precipitation of ischemia affecting cardiac myofibers in acute myocardial infarction and crescendo angina and in the evolution of progressive neuronal ischemia and necrosis of liquefactive type.
ER  -