TY  - JOUR
T1  - Paradoxical Systems of Patterned Autonomy in Uncoupled
Neoplastic Cell Proliferation and Spread
AU - , Lawrence M. Agius MD 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 1
IS  - 3
SP  - 273
EP  - 278
PY  - 2005
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2005.273.278
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2005.273.278
KW  - Paradoxical system
KW  -uncoupled
KW  -neoplastic
KW  -Cell
KW  -autonomy
AB  - Essential uncoupling of substrate metabolic and oxidative systems of supply and utilization by clones of neoplastic cells might correlate with various uncoupled phenomena of neoplastic cell proliferation and spread in specific patterns of carcinogenetic derivation and subsequent evolution. In this sense, the clonally based distributional patterns of intratumoral hypoxia and of various other pathobiologic effects of induced transformation ranging from angiogenesis to infiltrative spread of the neoplastic cells might constitute active modulation as exerted by active and passively acquired pathways of lost suppressor gene function. Indeed, one might speak of quantitative and qualitative systems of evolved influence that parallel each other and mirror fundamental uncoupling disturbances leading to a paradoxical series of systems characterized as patterned autonomous proliferation of malignant orimmortalized cells.
ER  -