TY  - JOUR
T1  - Loss of Synaptically Determined Viability of Neurons in Alzheimer Brain Atrophy
AU - , M. Lawrence. Agius 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 1
IS  - 2
SP  - 143
EP  - 148
PY  - 2005
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2005.143.148
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2005.143.148
KW  - Synaptically determind
KW  -brain athrophy
KW  -neuron
KW  -alzheimer
AB  - Multiple exogenously derived systems of promotion and of induced progression would perhaps actually participate within contextual frameworks of self-promotion as age-related dementia. Indeed, impaired synaptic connectivity and impaired synaptic integrity might assume pathogenic roles leading to aspects of both induced and self-promotion towards pathways of evolving brain atrophy. Even beyond simple schemes of induced effect or of self-progression, however, synaptic transmission or non-transmission might help characterize the Alzheimer process as systems of disturbance arising from micro-circulatory ischemia to lack of neurotrophic effect to systems of nonviability of neurons and of neuronal non-responsiveness. In simple terms, the specific associations of the Alzheimer process with aging would appear a specific characterization of synaptic pathobiology central to basic dynamics of dementia both as an organic atrophic state and also as persistently active pathways of progression once initiated.
ER  -