TY  - JOUR
T1  - Paraneoplasia as an Epigenetic Reflection of Systemic Dimensions of Potential Neoplastic Spread
AU - , M. Lawrence AU - , Agius 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 1
IS  - 2
SP  - 130
EP  - 136
PY  - 2005
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2005.130.136
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2005.130.136
KW  - Potential
KW  -neoplastic
KW  -spread
KW  -paraneoplasia
KW  -epigenetic reflection
KW  -systemic
KW  -evolution
AB  - Paraneoplasia as an essential system of involvement inherent to genetic attributes of neoplastic cellular proliferative events might actually involve an epigenetic process in a context of, however, systemic progression by the neoplasm. Indeed, a strict referential series of events as steps in systemic involvement of the patient by a proliferating and infiltrative neoplasm might simply constitute modes of how such a neoplasm
is, itself, a primarily systemic phenomenon with paradoxically focal manifestations that implicate however, progressive regional spread. In this sense, neoplasia might primarily constitute a process of systemic dimensions that is manifested also as a systemic phenomenon of paraneoplasia. In addition, one might speak of paraneoplastic syndromes as, for example, myasthenia gravis or endocrine manifestations, that parallel an associated neoplasm as a focal lesion of systemic dimensions. Indeed, genetic and epigenetic manifestations of neoplasia would involve different aspects of a phenomenon of systemic evolution that is not only manifested focally or regionally but is progressive mainly in terms of a focality that evolves in a strictly systemic context of genesis and epigenesis.
ER  -