TY  - JOUR
T1  - Molecular and Physiological Role of BMP 15 Gene Associated with
Ovulation Rate and Fertility of Iraq Goat
AU - Abdul-Kareem Hasan AL-Mutar, Hayder 
JO  - Journal of Animal and Veterinary Advances
VL  - 17
IS  - 5
SP  - 104
EP  - 110
PY  - 2018
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2018.104.110
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2018.104.110
KW  - BMP 15 gene
KW  -ovulation rate
KW  -fertility
KW  -goat
KW  -mutations
KW  -impregnated
AB  - In the present study, the investigation ovulation rate and fertility of Iraq goat by BMP-15 gene after
estrus synchronization by using 20 mg impregnated sponges with MAP for 12 days with 400 IU PMSG on day
before sponges withdrawal. All 25 Iraqi goats showed (100%) estrus after sponge withdrawal. Twinning
percentage 57.9% while single percentage 42.1%. The polymorphisms of BMP-15 gene were analyzed as a
genetic marker in Iraqi goats have shown that natural mutations in prolific goat breeds in BMP-15 gene
mutations are crucial for increasing litter size as well as ovulation rate. FecXR, FecXB and FecXH mutations
increased prolificacy in goats, PCR primers were used to polymorphisms in female goats by using PCR-RFLP
method. Although, the sequencing data showed four novels polymorphic sites in goat, mutations in base
number. 102 G>A, 156 T>G, 207 G>A and 218 G>T were identified, all these mutations were reported and
registered in NCBI with Accession No. of JX860305.1. Amino acid change is Arginine>Lysine,
Methionine>Arginine, Arginine>Glutamine and Valine>Leucine with Accession No. of AFX69269.1. The
conclusion of BMP15 gene may be a major gene which affects the prolificacy in goat and could provide basic
molecular data on the reproductive characteristics of Iraq breeds and a scientific basis for the conservation and
utilization of goat.
ER  -