TY  - JOUR
T1  - The Pharmacodynamic Effects of Amoxicillin Against <i>Staphylococcus aureus</i> in an In-vitro
Kinetic Model
AU - Zeng, Z.L. AU - Ding, H.Z. AU - Yang, D. AU - Yang, Y.H. 
JO  - Journal of Animal and Veterinary Advances
VL  - 15
IS  - 11
SP  - 69
EP  - 74
PY  - 2016
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2016.69.74
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2016.69.74
KW  - Pharmacodynamic
KW  -amoxycillin
KW  -effect
KW  -experimental period
KW  -bactericidal
AB  - The pharmacodynamic effect of amoxycillin
against Staphylococcus aureus was evaluated in an
in-vitro pharmacodynamic model. For amoxycillin peak
concentrations of 0.4, 1.0, 1.6 and 3.2 mg mL<sup>&#150;1</sup> and
half-lives of 2 and 5.5 h were examined. The bactericidal
effect was measured as the reduction in colony count (log
CFU mL<sup>&#150;1</sup>) during the experimental period and the
overall pharmacodynamic effect as the area under the
bacterial growth versus time curve (AUBC). In an <i>in vitro</i>
model with elimination half-life of 2 h, only 16 MIC
amoxicillin exhibited persistent killing of <i>Staphylococcus
aureu</i> with a bacterial number reduction of 2.51 lo<sup>&#150;1</sup>0. in
an <i>in vitro</i> model with simulative elimination half-life of
5.5 h, 5, 8 and 16 MIC amoxicillin exhibited persistent
killing of <i>Staphylococcus aureu</i> with a bacterial number
reduction of 2.42, 2.72 and 2.53 lo<sup>&#150;1</sup>0 noted during the
12 h, respectively. These data indicate that amoxicillin
reach the maximum killing at 5-folds of their MIC values
and the antimicrobial maintaining time is mainly
correlated with T>MIC. But during the whole
experimental period, bactericidal effect and bacterial
elimination were not achieved on Staphylococcus aureu
strains for which the MIC was 0.2 &#956;g mL<sup>&#150;1</sup>, even with a
Cmax/MIC ratio of 16.
ER  -