TY  - JOUR
T1  - Dose-Dependent Isoflurane-Sparing Effect of Maropitant in Dogs Undergoing Ovariohysterectomy
AU - Edamura, Kazuya AU - Okano, Kimiyoshi AU - Kimura, Taro 
JO  - Journal of Animal and Veterinary Advances
VL  - 14
IS  - 4
SP  - 95
EP  - 99
PY  - 2015
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2015.95.99
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2015.95.99
KW  - Dog isoflurane-sparing effect
KW  -maropitant
KW  -ovariohysterectomy
KW  -morphine
KW  -group
AB  - The dose-dependent isoflurane-sparing effect of maropitant in dogs undergoing Ovariohysterectomy (OHE) was investigated. Thirty six female dogs undergoing OHE were randomly divided into 3 groups. The MAR-1 group dogs were premedicated with 1 mg kg<SUP>-1</SUP> maropitant and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The MAR-5 group dogs were premedicated with 5 mg kg<SUP>-1</SUP> maropitant and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The MOR group dogs received saline and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The intraoperative isoflurane-sparing effect was compared among the groups. The mean intraoperative isoflurane requirements during the surgery were 1.88&plusmn;0.10, 1.76&plusmn;0.13 and 1.69&plusmn;0.16% in the MOR, MAR-1 and MAR-5 groups, respectively. The requirements of the MAR-1 and MAR-5 groups were significantly lower than that of the MOR group. The mean intraoperative isoflurane requirement during the surgery of the MAR-5 group was the lowest of all 3 groups. The isoflurane requirement at 40 min after the start of surgery of the MAR-5 group was significantly lower than that of the MAR-1 group. Preoperative administration of maropitant effectively reduces the intraoperative isoflurane requirement in a dose-dependent manner.
ER  -