TY  - JOUR
T1  - Noni Fruit Extract Induces Effective Control of Lesions in Mice Infected with <I>Leishmania amazonensis</I>
AU - Mondego-Oliveira, Renata AU - Almeida-Souza, Fernando AU - Cortez de Sa, Joicy AU - Oliveira Torres, Mylena Andrea AU - de Andrade, Fabio Henrique Evangelista AU - Melo, Ferdinan Almeida AU - Calabrese, Katia da Silva AU - Abreu-Silva, Ana Lucia 
JO  - Journal of Animal and Veterinary Advances
VL  - 14
IS  - 6
SP  - 151
EP  - 154
PY  - 2015
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2015.151.154
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2015.151.154
KW  - Experimental infection
KW  -Morinda citrifolia
KW  -murine leishmaniasis
KW  -susceptible mice
KW  -extracellular
AB  - The present study evaluated the effect of <I>Morinda citrifolia</I> crude extract on mice infected with <I>Leishmania amazonensis</I>. Both infected and untreated animals displayed severe extracellular matrix destruction, hyperplasia of the white pulp of the spleen and inflammatory cell infiltration in the liver. In contrast, animals treated with <I>M. citrifolia</I> crude extract displayedintense extracellular matrix production, characterized by the predominance of mature collagen and no alterations to the analyzed organs. The results revealed regression of lesions caused by <I>L. amazonensis</I> in the groups treated with noni extract which demonstrates that <I>M. citrifolia</I> provides effective control of the lesions caused by the infection.
ER  -