TY  - JOUR
T1  - Atherosclerosis and Animal Models
AU - Liu, Enqi AU - Zhang, Guangwei AU - Chen, Yulong AU - Lin, Yan 
JO  - Journal of Animal and Veterinary Advances
VL  - 13
IS  - 7
SP  - 441
EP  - 448
PY  - 2014
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2014.441.448
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2014.441.448
KW  - Atherosclerosis
KW  -animal model
KW  -mouse
KW  -rabbits
KW  -cardiovascular disease
AB  - Cardiovascular disease is currently the major cause of mortality 
  and morbidity in developing and developed countries. Atherosclerosis is the 
  core of cardiovascular disease and is complex inflammatory process. Many animal 
  species have been used to investigate the pathogenesis of atherosclerosis. However, 
  the most useful animal models have been restricted to genetically modified mice 
  or larger animal models including rabbits, pig and non-human primates. Mouse 
  models are widely used for atherosclerosis research due to genetic manipulation. 
  Murine atherosclerosis are different from that of human. Thus, the models are 
  used for investigation of biological processes of atherosclerosis. Rabbits do 
  not develop spontaneous atherosclerosis but they are highly responsive to cholesterol 
  diet and develop plaque in a short time. Pig and monkey are better suitable 
  models because their plasma levels and atherosclerotic plaque are similar to 
  that of human. However, these models are not widely used. Relatively high cost 
  and ethical concern may be major causes.
ER  -