TY  - JOUR
T1  - Evaluation of the Anti-Proliferative Activity of Natural Lipid Preparations 
  Against Tumor Cell Lines
AU - Bodkowski, Robert AU - Patkowska-Sokola, Bozena AU - Filip-Psurska, Beata AU - Kempinska, Katarzyna AU - Wietrzyk, Joanna AU - Czyz, Katarzyna AU - Walisiewicz-Niedbalska, Wieslawa AU - Usydus, Zygmunt 
JO  - Journal of Animal and Veterinary Advances
VL  - 13
IS  - 4
SP  - 257
EP  - 266
PY  - 2014
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2014.257.266
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2014.257.266
KW  - Lipid preparations enriched in CLA
KW  -VA
KW  -EPA
KW  -DHA
KW  -bioactive lipid complexes
KW  -cancer
KW  -anti-proliferative activity
KW  -acid mixtures
AB  - A few substances in the human diet have been identified as anticarcinogens but most of them are present in trace concentrations. Lipid preparations enriched in biologically active fatty acids like CLA, VA, EPA and DHA were used for Bioactive Lipid Complexes (BLCs) preparation. The compounds were examined for their antiproliferative activity <I>in vitro</I> against human lung (A549), melanoma (Hs294T), colon (HT-29), breast cancer (MCF-7) and promyelocytic leukemia (HL-60) cells. All compounds were also tested in combined treatment with several cytostatic agents. From all tested enriched lipid preparations and bioactive lipid complexes the compound BLC-2 containing 36.7% of CLA and 45.3% of EPA+DHA revealed the highest antiproliferative activity in tested human cancer models. Its activity was comparable to this of CLA-1 (98% c9, t11 C18:2 CLA) used alone as a reference. The results indicate that anti-proliferative activity of unsaturated fatty acid mixtures is associated with their composition.
ER  -