TY  - JOUR
T1  - Expression of Estrogen Receptor-α like Immunoreactivity in the Endometrium and Superoxide Dismutase Activity after Addition of Estrogen in Culture Medium of Endometrial Epithelial Cells in the Rabbit
AU - Kawakami, Eiichi AU - Wada, Miho AU - Yokosuka, Makoto AU - Nakada, Tomoaki AU - Kobayashi, Masanori AU - Hori, Tatsuya 
JO  - Journal of Animal and Veterinary Advances
VL  - 13
IS  - 20
SP  - 1139
EP  - 1142
PY  - 2014
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2014.1139.1142
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2014.1139.1142
KW  - Endometrial epithelial cell
KW  -estrogen receptor α
KW  -rabbit
KW  -superoxide dismutase
KW  -uterine adenocarcinoma
AB  - The purpose of this study is to reveal the effect of estrogen-inducing SOD activity on the endometrium of domestic rabbits. Researchers measured Superoxide Dismutase (SOD) activity to investigate the reason of occurrence of popular uterine adenocarcinoma in rabbits in estradiol-17β-stimulated endometrium epithelial cell culture. Then, we also examined the distribution of cells  expressing Estrogen Receptor α (ERα)-like Immunoreactivites (ERα-like-IR) in the uterus prone to developing adenocarcinoma. The addition of estradiol-17β to the primary culture of endometrial epithelial cells obviously decreased SOD activity. Moreover, the areas of endometrium in which uterine glands were confined in control rabbits and notably larger in rabbits with glandular hyperplasia of the uterus compared in normal dog uterus that the occurrence of uterine adenocarcinoma is rare. ERα-like-IR cells were found in all proliferating glands in rabbits with hyperplasia.
ER  -