TY  - JOUR
T1  - Polymorphism of Cytochrome P450 Aromatase Gene and its Association with Selected Reproductive Traits in Polish Holstein-Friesian Cattle<SUP>
AU - Wierzbicki, Heliodor AU - Bula, Weronika AU - Kmiec, Marek 
JO  - Journal of Animal and Veterinary Advances
VL  - 13
IS  - 18
SP  - 1098
EP  - 1103
PY  - 2014
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2014.1098.1103
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2014.1098.1103
KW  - reproductive traits
KW  -CYP19 gene
KW  -cytochrome P450 aromatase
KW  -dairy cattle
KW  -cows
AB  - The aim of the study was to analyze the polymorphism of cytochrome P450 aromatase gene (<I>CYP19</I>) and the search for the association between the genotypes of two polymorphic sites (CYP19/Cyfr13I and CYP19/PvuII) in the P1.1 promoter region of the <I>CYP19</I> gene and the age at first calving and calving interval length in Polish Holstein-Friesian cattle. The study used a data set of 909 Polish Holstein-Friesian cows born in the years 1991-1998 and kept in five farms. The analysis of the <I>CYP19</I> gene polymorphism showed that homozygous AA genotype was most common in both CYP19/Cyfr13I and CYP19/PvuII loci while the least common, also in both loci was the BB genotype. The frequency of the A allele at both loci significantly exceeded the frequency of the B allele. The earliest age at first calving for both CYP19/Cyfr13I and CYP19/PvuII loci demonstrated BB homozygous cows and the latest was found for AA homozygotes. The longest first calving interval was characteristic of cows that were homozygous for the A allele at the CYP19/Cyfr13I locus whereas with respect to the CYP19/PvuII locus, heterozygotes had the longest first calving interval. The shortest first calving interval showed BB homozygotes at both investigated loci. Heterozygotes at the CYP19/Cyfr13I locus had the shortest second calving interval whereas regarding the CYP19/PvuII locus, the shortest second calving interval was found for AA homozygotes.<B>
ER  -